SUNBRIGHT® DSPE-020CN (DSPE-PEG)

SUNBRIGHT DSPE-020CN (DSPE-PEG2000) can be applied to lipid nanoparticle (LNP) and liposomal formulations to extend the half-life in the bloodstream. Coating of the surface of LNPs or liposomes with polyethylene glycol (PEG) suppresses drug clearance in vivo by the reticuloendothelial system, thereby prolonging the half-life of the drug. DSPE-020CN has a carbamate linkage that is resistant to hydrolysis between the PEG moiety and DSPE (distearoyl phosphatidylethanolamine), and therefore is used for commercial production of PEGylated liposomes. DSPE-020CN can also be used as emulsifiers and stabilizers of microspheres in aqueous solutions.