{"product_id":"sunbright-me-400al2","title":"SUNBRIGHT® ME-400AL2","description":"\u003cp\u003eSUNBRIGHT® ME-400AL2 is a methoxy PEG aldehyde with a 40,000 Da PEG chain. The aldehyde group selectively reacts with amine or aminooxy groups on bioactive molecules. By leveraging the pKa difference between the ε-amine of lysines and the α-amine of the N-terminus, the aldehyde group can be used for selective PEGylation under slightly acidic conditions (pH 4.5–6). This approach minimizes off-target reactions at lysine side chains, allowing preferential conjugation at the protein’s N-terminus and resulting in more homogeneous PEG–protein conjugates. Moreover, the initial Schiff base (imine) formed upon reaction with amine groups can be stabilized via reductive amination to yield a stable secondary amine linkage. This N-terminal PEGylation strategy has been employed in the development of commercial therapeutics such as Neulasta® (pegfilgrastim) and its biosimilars, demonstrating its utility and commercial viability in the biopharmaceutical field.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"NOF AMERICA","offers":[{"title":"1g amber glass bottle","offer_id":54966337241312,"sku":"bvy1789666082082","price":203.28,"currency_code":"USD","in_stock":true},{"title":"10g aluminum pouch","offer_id":54966337274080,"sku":"ahl1789666082083","price":1777.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0810\/5613\/7440\/files\/sunbright-me-400al2_1.jpg?v=1789666084","url":"https:\/\/yogabalanceclad.shop\/products\/sunbright-me-400al2","provider":"My Store","version":"1.0","type":"link"}